Molecular Basis of Amyloid Polymorphism: Multiple Misfolding Pathways
نویسندگان
چکیده
منابع مشابه
Molecular basis for amyloid-β polymorphism
Amyloid-beta (Aβ) aggregates are the main constituent of senile plaques, the histological hallmark of Alzheimer’s disease. Aβ molecules form β-sheet containing structures that assemble into a variety of polymorphic oligomers, protofibers, and fibers that exhibit a range of lifetimes and cellular toxicities. This polymorphic nature of Aβ has frustrated its biophysical characterization, its struc...
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ژورنال
عنوان ژورنال: Journal of Physical Chemistry & Biophysics
سال: 2013
ISSN: 2161-0398
DOI: 10.4172/2161-0398.1000e112